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System No. U0002-3107201416150800
Title (in Chinese) 隅角閉鎖型青光眼影響視神經底盤之力學分析
Title (in English) Mechanical analysis in lamina cribrosa influence from angle-closure glaucoma
Other Title
Institution 淡江大學
Department (in Chinese) 機械與機電工程學系碩士班
Department (in English) Department of Mechanical and Electro-Mechanical Engineering
Other Division
Other Division Name
Other Department/Institution
Academic Year 102
Semester 2
PublicationYear 103
Author's name (in Chinese) 呂岳翰
Author's name(in English) Yue-Han Lyu
Student ID 601370116
Degree 碩士
Language Traditional Chinese
Other Language
Date of Oral Defense 2014-07-10
Pagination 65page
Committee Member advisor - 李宗翰
co-chair - 洪祖昌
co-chair - 黃曼菁
Keyword (inChinese) 隅角閉鎖型青光眼
Keyword (in English) Angle-closure glaucoma
intraocular pressure
optic nerve
lamina cribrosa
Other Keywords
Abstract (in Chinese)
Abstract (in English)
In this study, main research is focus on angle-closure glaucoma injure the laminacribrosa of eye ball. Due to the drainage system of aqueous humor blocked, cause the intraocular pressure of anterior chamber elevated. Intraocular pressure transfers load in glaucoma patients, leading to the optic nerve suffer oppression and yield visual field defect. So this study designed a complete eye model to analysis generating the pathogenesis of angle-closure glaucoma.We obtain the pressure values of the anterior chamber in this results, and it conform the range of clinical pressure values. From the phenomenon of stress distribution inside the eye, the maximum stress concentrate at posterior sclera and lamina cribrosa. Our study also conducted investigate for patients with different situations. Found that the eye organization are the same Young’s modulus, but the higher IOP  make the phenomenon of stress concentration obviously in lamina cribrosa. And the same IOP, but the higher Young’s modulus of organization, it the best of ability to withstand the load.Lower Young’s modulus of eye organization, yielding the higher strain, and caused the great displacement in lamina cribrosa. This study analyzed the results of angle-closure glaucoma, make the patient to better understanding of their condition, and offer the important information to the next research.
Other Abstract
Table of Content (with Page Number)

第一章序論 1
1-1前言 1
1-2研究背景與動機 3
1-3文獻回顧 6
第二章研究方法 11
2-1有限元素法概論 11
2-2應用軟體 12
2-3研究過程 14
第三章分析理論 16
3-1Continuity Equation 18
3-2Momentum Equation 18
3-3Compressible Energy Equation 19
3-4 Pressure 20
3-5收斂檢測 21
第四章參數條件設定 23
4-1定義分析元素 23
4-1-1 流體元素分析 23
4-1-2 結構體元素分析 24
4-2材料性質 25
4-3模型建立 28
4-4初始條件設定 31
4-5負載條件設定 32
第五章數值模型分析結果 33
5-1隅角閉鎖型青光眼 33
5-2結果分析 34
5-2-1流體分析結果 34
5-2-2結構體分析結果 37
5-3結果驗證 39
5-4結果討論 44
5-4-1不同的眼壓與相同材料參數做比較討論 44
5-4-2相同的眼壓與不同的材料參數做比較討論 50
第六章結論與未來展望 59
6-1結論 59
6-2未來展望 61
參考文獻 62


圖1-1青光眼視野缺損的演進[5] 3
圖1-2房水流動示意圖[9] 5
圖2-1研究過程與流程圖 15
圖4-1FLUID 142元素圖[31] 24
圖4-2SOLID 45元素圖[31] 25
圖4-3眼球2D草圖繪製 30
圖4-4眼球模型剖面圖 30
圖4-5房水流場設定圖 31
圖4-6邊界條件示意圖 32
圖5-1隅角閉鎖型青光眼房水流動示意圖[41] 34
圖5-2隅角閉鎖型青光眼前後房壓力分布圖 35
圖5-3隅角閉鎖型青光眼前後房流場圖 36
圖5-4隅角閉鎖型青光眼前後房流線圖 36
圖5-5隅角閉鎖型青光眼之應力分布圖 38
圖5-6隅角閉鎖型青光眼應變分布圖 38
圖5-7隅角閉鎖型青光眼位移圖 39
圖5-8隅角閉鎖型青光眼與文獻[19]比較之應力分布圖 42
圖5-9隅角閉鎖型青光眼與文獻[24]比較之應力分布圖 43
圖5-10隅角閉鎖型青光眼與文獻[24]比較之應變分布圖 43
圖5-11不同眼壓與相同楊氏係數之應力分布比較圖 47
圖5-12不同眼壓與相同楊氏係數之應變分布比較圖 48
圖5-13不同眼壓與相同楊氏係數之位移比較圖 49
圖5-14相同眼壓(20mmHg)與不同楊氏係數之應力分布圖 52
圖5-15相同眼壓(20mmHg)與不同楊氏係數之應變分布圖 53
圖5-16相同眼壓(20mmHg)與不同楊氏係數之位移圖 54
圖5-17相同眼壓(40mmHg)與不同楊氏係數之應力分布圖 56
圖5-18相同眼壓(40mmHg)與不同楊氏係數之應變分布圖 57
圖5-19相同眼壓(40mmHg)與不同楊氏係數之位移圖 58


表4-1房水材料參數表 26
表4-2模擬結構體眼球組織之材料參數表 28
表5-1隅角閉鎖型青光眼與文獻[19]之尺寸對照表 41
表5-2隅角閉鎖型青光眼與文獻[19]之楊氏係數對照表 41
表5-3隅角閉鎖型青光眼與文獻[19]之結果倍數比較表 41
表5-4隅角閉鎖型青光眼與文獻[24]之尺寸對照表 42
表5-5隅角閉鎖型青光眼與文獻[24]之楊氏係數對照表 43
表5-6不同眼壓與相同楊氏係數數據表 46
表5-7相同的眼壓與不同的楊氏係數數據表 51
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