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System No. U0002-2407201514414900
Title (in Chinese) 人種及年齡層與隅角閉鎖型青光眼之視神經盤受力分佈探討
Title (in English) Mechanical analysis of angle-closure glaucoma in optic disc of different ethnicities and ages
Other Title
Institution 淡江大學
Department (in Chinese) 機械與機電工程學系碩士班
Department (in English) Department of Mechanical and Electro-Mechanical Engineering
Other Division
Other Division Name
Other Department/Institution
Academic Year 103
Semester 2
PublicationYear 104
Author's name (in Chinese) 卓立
Author's name(in English) Li Chow
Student ID 602370222
Degree 碩士
Language Traditional Chinese
Other Language
Date of Oral Defense 2015-07-01
Pagination 86page
Committee Member advisor - 李宗翰
co-chair - 史建中
co-chair - 黃曼菁
co-chair - 李宗翰
Keyword (inChinese) 隅角閉鎖型青光眼
眼壓
視神經盤
人種
年齡層
Keyword (in English) Angle-closure glaucoma
intraocular pressure
optic disc
ethnicities
ages
Other Keywords
Subject
Abstract (in Chinese)
本文主要研究隅角閉鎖型青光眼對眼球視神經盤的損害,隅角閉鎖型青光眼是由於房水與虹膜間流動受阻造成前房眼壓急遽升高,壓力傳遞到眼球視神經盤後導致受損,引發視野缺損的情形。本研究設計完整的眼球模型,藉由隅角閉鎖型青光眼的發病機制進行模擬與分析,進而觀察視神經盤的受損情形。
本研究針對白種人、亞洲人、非洲人三種人種的視神經盤特性做出相應的眼球模型,在觀察眼球內部應力分佈後發現,在單一探討視神經盤差異的情況下,非洲人較亞洲人及白種人受到的視神經盤損害最為嚴重,另外本文也模擬了三種人種在不同年齡層及不同眼壓下之眼球內部受力情形。本研究模擬隅角閉鎖型青光眼分析之結果,提供往後相關研究一個重要的依據。
Abstract (in English)
In this study, research is focused mainly on injures to the eye ball due to angle-closure glaucoma. Due to blockage of the drainage system of the aqueous humor, the intraocular pressure of anterior chamber is elevated. Intraocular pressure transfers load in glaucoma patients, leading to the optic nerve suffering high pressures, yielding visual field defects. This study designed a complete eye model to analyze the pathogenesis of angle-closure glaucoma. The pressure values of the anterior chamber were obtained, and they conform to the range of accepted clinical pressure values. From the phenomenon of stress distribution inside the eye, the maximum stress concentration was found at the posterior sclera and optic disc.
In this study, we changed the models to reflect the characteristics of the optic discs of those of Asian, African and Caucasian descent. After observation of the stress distribution inside the eye, due to differences in size of the optic disc of each ethnicity, it was found that Africans suffered more serious damage to the optic disc than Asians or Caucasians. We also simulated the stress distribution inside the eye of each of the three ethnicities at different ages and different IOPs (intraocular pressure) under each situation. This study analyzes the results of angle-closure glaucoma, and offers important information for future research.
Other Abstract
Table of Content (with Page Number)
目錄
第一章序論	1
1-1 前言	1
1-2 研究背景與動機	3
1-3 隅角閉鎖型青光眼	6
1-4 文獻回顧	7
第二章研究方法	13
2-1 有限元素法概論	13
2-2 應用軟體	14
2-3 研究過程	16
第三章分析理論	18
3-1 連續性方程式( Continuity Equation )	19
3-2 動量方程式( Momentum Equation )	20
3-3 可壓縮能量方程式( Compressible Energy Equation )	21
3-4 壓力方程式( Pressure )	22
3-5 收斂檢測	23
第四章參數條件設定	24
4-1 定義分析元素	24
4-1-1 流體元素分析	24
4-1-2 結構體元素分析	25
4-2 材料性質	26
4-3 模型建立	29
4-4 初始條件設定	33
4-5 負載條件設定	34
第五章數值模型分析結果	36
5-1 結果分析	36
5-1-1 流體分析結果	36
5-1-2 結構體分析結果	39
5-2 結果驗證	42
5-3 結果討論	48
5-3-1 白種人、亞洲人及非洲人視神經盤結構差異之討論	49
5-3-2白種人、亞洲人及非洲人不同眼壓影響之討論	54
5-3-3白種人、亞洲人及非洲人不同材料參數影響之討論	63
第六章結論與未來展望	78
6-1 結論	78
6-2 未來展望	80
參考文獻	81




























圖目錄
圖1 1青光眼視野缺損示意圖	3
圖1-2房水流動示意圖[11]	5
圖1-3隅角閉鎖型青光眼房水流動示意圖[12]	6
圖2-1研究過程與流程圖	17
圖4-1 FLUID 142元素圖[41]	25
圖4-2 SOLID 45元素圖[41]	26
圖4-3眼球構造圖[50]	31
圖4-4眼球模型剖面圖	32
圖4-5完整眼球3D模型圖	32
圖4-6房水流場設定圖	33
圖4-7眼球結構示意圖[55]	35
圖4-8邊界條件示意圖	35
圖5-1隅角閉鎖型青光眼前後房壓力分布剖面圖	38
圖5-2隅角閉鎖型青光眼前後房流場剖面圖	38
圖5-3隅角閉鎖型青光眼前後房流線剖面圖	39
圖5-4隅角閉鎖型青光眼之應力分布圖	41
圖5-5隅角閉鎖型青光眼應變分布圖	41
圖5-6正常人眼壓前後房壓力剖面圖	44
圖5-7正常人眼壓之結構體應力數值示意圖	44
圖5-8隅角閉鎖型青光眼前後房壓力剖面圖	45
圖5-9隅角閉鎖型青光眼之結構體應力數值示意圖	45
圖5-10隅角閉鎖型青光眼與文獻[29]比較之應力分布圖	47
圖5-11白種人、亞洲人及非洲人眼球結構體應力分佈比較圖	51
圖5-13白種人、亞洲人及非洲人眼球結構體應變分佈比較圖	53
圖5-14白種人不同眼壓與相同材料參數之應力分布比較圖	57
圖5-15亞洲人不同眼壓與相同材料參數之應力分布比較圖	58
圖5-16非洲人不同眼壓與相同材料參數之應力分布比較圖	59
圖5-17白種人不同眼壓與相同材料參數之應變分布比較圖	60
圖5-18亞洲人不同眼壓與相同材料參數之應變分布比較圖	61
圖5-19非洲人不同眼壓與相同材料參數之應變分布比較圖	62
圖5-20白種人三年齡層眼壓10mmHg之應力分布比較圖	65
圖5-21亞洲人三年齡層眼壓10mmHg之應力分布比較圖	66
圖5-22非洲人三年齡層眼壓10mmHg之應力分布比較圖	67
圖5-23白種人三年齡層眼壓10mmHg之應變分布比較圖	68
圖5-24亞洲人三年齡層眼壓10mmHg之應變分布比較圖	69
圖5-25非洲人三年齡層眼壓10mmHg之應變分布比較圖	70
圖5-26白種人三年齡層眼壓50mmHg之應力分布比較圖	72
圖5-27亞洲人三年齡層眼壓50mmHg之應力分布比較圖	73
圖5-28非洲人三年齡層眼壓50mmHg之應力分布比較圖	74
圖5-29白種人三年齡層眼壓50mmHg之應變分布比較圖	75
圖5-30亞洲人三年齡層眼壓50mmHg之應變分布比較圖	76
圖5-31非洲人三年齡層眼壓50mmHg之應變分布比較圖	77









表目錄
表4-1房水材料參數表	26
表4-2模擬結構體眼球組織之材料參數表	29
表5-1隅角閉鎖型青光眼與文獻[21]之尺寸對照表	43
表5-2隅角閉鎖型青光眼與文獻[21]之楊氏係數對照表	43
表5-3隅角閉鎖型青光眼與文獻[21]之結果倍數比較表	43
表5-4隅角閉鎖型青光眼與文獻[28]之尺寸對照表	47
表5-5隅角閉鎖型青光眼與文獻[28]之楊氏係數對照表	47
表5-6白種人、亞洲人及非洲人視神經盤大小對照表	50
表5-7不同人種、眼壓與相同楊氏系數數據表	56
表5-8相同的眼壓與不同的楊氏係數數據表	64
References
參考文獻
1.	http://news.cts.com.tw/cts/general/201503/201503051589564.html#.VVGQyz-SxDQ

2.	https://www1.cgmh.org.tw/intr/intr2/c4340/media/media_b02.html

3.	Y. Yokoyama, et al. “Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk,” Clinical Ophthalmology,  pp.1721-1727 (2011)

4.	http://www.kmuh.org.tw/www/kmcj/data/8807/4273.htm

5.	http://www.kgh.com.tw/health/09-01.HTML

6.	Hyun Kyung Cho, Chang Won Kee, “Population-based glaucoma prevalence studies in Asians,” Survey Ophthalmology, Vol.59, pp.434-447 (2014)

7.	http://cht.a-hospital.com/w/%E9%9D%92%E5%85%89%E7%9C%BC

8.	L. Kagemann, et al. “3D visualization of aqueous humor outflow structures in-situ in humans,” Experimental Eye Research, Vol.93, pp.308-315 (2011)
9.	http://depart.femh.org.tw/oph/oph/ch/MedicalTeam-Glaucoma-1.html

10.	G. Guidoboni, A. Harris, J. C. Arciero, Julia C Arciero, B. A. Siesky, A. Amireskandari, A. L. Gerber, "Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents," Journal of coupled systems and multiscale dynamics, Vol.04, pp.01-21 (2013)

11.	http://m.haodf.com/touch/zhuanjiaguandian/chengjinwei_539425565.htm 

12.	http://flickrhivemind.net/User/ambioct/Interesting

13.	R. C. Tripathi, B. J. Tripathi, “Functional anatomy of the anterior chamber angle,” Biomedical Foundations of Ophthalmology Philadelphia,  pp.197 (1982)

14.	J. B. Jonas, et al. “Optic Disc, Cup and Neuroretinal Rim Size, Configuration and Correlations in Normal Eyes,” Investigative Ophthalmology and Visual Science, Vol. 29, pp.1151-1158 (1988 )

15.	T. W. Olsen, et al. “Human Sclera: Thickness and Surface Area,” American Journal of Ophthalmology, Vol.125, pp. 237-241 (1998)

16.	M. Johnson, K. Erickson “Mechanisms and Routes of Aqueous Humor Drainage,” Principles and Practice of Ophthalmology, Vol.01  (2000)

17.	A. Villamarin, et al. “3D simulation of the aqueous flow in the human eye,” Medical Engineering and Physics, Vol.34, pp.1462-1470 (2012)

18.	J. S. M. Lai, R. A. Gangwani “Medication-induced acute angle closure attack,” Hong Kong Med J, Vol.18, No.2 (2012) 

19.	D. B. Yan, et al. “Deformation of the lamina cribrosa by elevated intraocular pressure,” British Journal of Ophthalmology, Vol.78, pp.643-648 (1994)

20.	C. F. Burgoyne, et al. “Measurement of Optic Disc Compliance by Digitized Image Analysis in the Normal Monkey Eye,” Ophthalmology, Vol.102, pp.1790-1799 (1995)

21.	E. Uchio, S. Ohno, J. Kudoh, K. Aoki, L. T. Kisielewicz “ Simulation model of an eyeball based on finite element analysis on a supercomputer ,” British Journal of Ophthalmology, Vol.83, pp.1106–1111 (1999)


22.	A. J. Bellezza, R. T. Hart, C. F. Burgoyne “ The optic nerve head as a biomechanical structure: initial finite element modeling,” Investigative Ophthalmology and Visual Science, Vol.41, pp.2991-3000 (2000)

23.	E. M. Hoffmann. L. M. Zangwill, J. G. Crowston, R. N. Weinreb, "Optic Disk Size and Glaucoma," Survey Ophthalmology, Vol.52, pp. 32–49 (2007)

24.	C. Zangalli, S. R. Gupta, G. L. Spaeth, "The disc as the basis of treatment for glaucoma," Saudi Journal of Ophthalmology, Vol.25, pp.381-387 (2011)

25.	M. J. A. Girard, et al. “ Peripapillary and Posterior scleral mechanics-Part II: Experimental and inverse finite element characterization,” Journal of Biomechanical Engineering, Vol.131 (2009)

26.	R. E. Norman, et al. “Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma,” Experimental Eye Research, Vol.93, pp. 4-12 (2011)

27.	Y. Agoumi, et al. “Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls,” Ophthalmology, Vol.118, pp.52-59 (2011)

28.	http://ophthalmology.medicine.pitt.edu/personnelDetail.asp?pid=4444&id=127&ptype=2&pnavcat=2

29.	I. A. Sigal, et al. “Finite element modeling of optic nerve head biomechanics” Investigative Ophthalmology and Visual Science, Vol.45, pp.4378-4387 (2004)

30.	黃士豪,「眼球前後房房水壓力數值模擬分析研究」,淡江大學機械與機電工程研究所,2008。

31.	邱湘傑,「運用ANSYS FLOTRAN CFD於隅角閉鎖型青光眼在玻璃體外部所造成之壓力分析」,淡江大學機械與機電工程研究所,2009。

32.	蕭天偉,「超音波晶體乳化手術併人工水晶體植入於隅角閉鎖型青光眼治療之研究」,淡江大學機械與機電工程研究所,2010。

33.	陳定杰,「超音波晶體乳化手術併人工水晶體植入後隅角閉鎖型青光眼治療之分析與研究」,淡江大學機械與機電工程研究所,2011。

34.	賴俊良,「隅角閉鎖型青光眼於視神經盤之壓力分析」,淡江大學機械與機電工程學研究所,2013。

35.	S. Schutte, et al. “A finite-element analysis model of orbital biomechanics,” Vision Research, Vol.46, pp.1724-1731 (2006)

36.	呂岳翰,「隅角閉鎖型青光眼影響視神經底盤之力學分析」,淡江大學機械與機電工程學研究所,2014。

37.	Jing Wu, M. A. Nasserib, M. Ederc, M. A. Gavaldonc, C. P. Lohmannd, A. Knollc," The 3D Eyeball FEA Model with Needle Rotation," APCBEE Procedia, Vol.7, pp.4 – 10 ( 2013 )

38.	M. E. Kavousanakis, N. G. Kalogeropoulos, D. T. Hatziavramidis, "Computational modeling of drug delivery to the posterior eye," Chemical Engineering Science, Vol.108, pp.203–212 (2014)

39.	http://zh.wikipedia.org/zh-tw/%E6%9C%89%E9%99%90%E5%85%83%E5%88%86%E6%9E%90

40.	http://zh.wikipedia.org/zh-tw/%E5%86%AF%E5%BA%B7
41.	http://www.ansys.com/

42.	J. J. Heys, V. H. Barocas, “A boussinesq model of natural convection in the human eye and the formation of Krukenbergs spindle,” Annals of Biomedical Engineering, Vol.30, pp.392-401 (2002)

43.	R. Amini, J. E. Whitcomb, M. K. Al-Qaisi, T. Akkin, S. Jouzdani, S. Dorairaj, T. Prata, E. Illitchev, J. M. Liebmann,R. Ritch, V. H. Barocas, "The posterior location of the dilator muscle induces anterior iris bowing during dilation, even in the absence of pupillary block," Investigative Ophthalmology and Visual Science, Vol.53, pp.1188-94 (2012)

44.	K. Jyoti, ”Numerical Solution of Flow Resistance in Outflow Pathway and Intravitreal Drug Delivery in Vitrectomised Eyes,” (2002)

45.	J. L. Battaglioli, R. D. Kamm “Measurements of the compressive properties of scleral tissue,” Investigative Ophthalmology and Visual Science, Vol.25, pp.59-65 (1984)

46.	I. A. Sigal, et al. “IOP-induced lamina cribrosa deformation and scleral canal expansion: independent or related?” Investigative Ophthalmology and Visual Science, Vol.52, pp.9023-9032 (2011)

47.	J. D. Stitzel, et al. “A nonlinear finite element model of the eye with experimental validation for the prediction of globe rupture,” Stapp Car Crash Journal, Vol.46, pp.81-102 (2002)

48.	D. A. Atchison, G. Smith “Optics of the human eye,” Chapter.1, pp.3-10 (2001)

49.	http://www.nei.nih.gov/eyeonnei/visionary/archive/0210.asp

50.	http://telemedicine.orbis.org/data/1/rec_docs/87_Ch%203%20-%20Summary%20of%20the%20Gross%20Anatomy%20of%20the%20Extraocular%20Muscles,%20p.%2038-51.pdf

51.	http://blog.remakehealth.com/blog_Healthcare_Consumers-0/bid/11597/What-does-an-MRI-of-the-Orbits-Eyes-show

52.	G. K. Noorden, “Summary of the gross anatomy of the extraocular muscles,” In Binocular Vision and Ocular Motility, 4thed, E. A. Klein,  K. H. Falk, editors. S. Louis, C. V. Mosby, pp. 49-50 (1990)

53.	Y. Shauly, B. Miller “ Tenon’s Capsule: Ultrastructure of Collagen Fibrils in Normals and Infantile Esotropia,” Investigative Ophthalmology and Visual Science, Vol.33, pp.651-656 (1992)

54.	Y. R. Sharma, R. Sudan” Concise Textbook of Ophthalmology,” Publisher: Elsevier (2005)

55.	http://eyecenter.com.ua/en/doctor/discus_club/02.htm
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