隅角閉鎖型青光眼對眼球視神經篩板造成傷害是本文主要的研究重點，由於房水排出受阻導致前房眼壓異常升高，青光眼在眼內產生的壓力具有傳遞的情形，導致視神經受到壓迫而產生視野缺損。因此本研究設計完整的眼球模型，並藉由隅角閉鎖型青光眼的生成與發病機制進行模擬與分析。分析結果得到的前房壓力值，符合隅角閉鎖型青光眼臨床壓力值範圍，而從眼球內部的應力分布現象來看，最大應力集中在鞏膜後端與篩板處。本研究針對不同情況的患者進行探討，發現組織楊氏係數相同，但眼壓越高的人，視神經篩板處應力集中現象越明顯。而眼壓值一樣，組織楊氏係數較高的人，抗壓迫能力最好，組織楊氏係數較低的人，產生較高的應變值，在篩板處造成極大的位移量。本研究模擬隅角閉鎖型青光眼之分析結果，給予患者對自身病情更加瞭解，也提供往後相關研究一個重要的依據。

In this study, main research is focus on angle-closure glaucoma injure the laminacribrosa of eye ball. Due to the drainage system of aqueous humor blocked, cause the intraocular pressure of anterior chamber elevated. Intraocular pressure transfers load in glaucoma patients, leading to the optic nerve suffer oppression and yield visual field defect. So this study designed a complete eye model to analysis generating the pathogenesis of angle-closure glaucoma.We obtain the pressure values of the anterior chamber in this results, and it conform the range of clinical pressure values. From the phenomenon of stress distribution inside the eye, the maximum stress concentrate at posterior sclera and lamina cribrosa. Our study also conducted investigate for patients with different situations. Found that the eye organization are the same Young’s modulus, but the higher IOP  make the phenomenon of stress concentration obviously in lamina cribrosa. And the same IOP, but the higher Young’s modulus of organization, it the best of ability to withstand the load.Lower Young’s modulus of eye organization, yielding the higher strain, and caused the great displacement in lamina cribrosa. This study analyzed the results of angle-closure glaucoma, make the patient to better understanding of their condition, and offer the important information to the next research.

目錄

第一章序論 1
1-1前言 1
1-2研究背景與動機 3
1-3文獻回顧 6
第二章研究方法 11
2-1有限元素法概論 11
2-2應用軟體 12
2-3研究過程 14
第三章分析理論 16
3-1Continuity Equation 18
3-2Momentum Equation 18
3-3Compressible Energy Equation 19
3-4 Pressure 20
3-5收斂檢測 21
第四章參數條件設定 23
4-1定義分析元素 23
4-1-1 流體元素分析 23
4-1-2 結構體元素分析 24
4-2材料性質 25
4-3模型建立 28
4-4初始條件設定 31
4-5負載條件設定 32
第五章數值模型分析結果 33
5-1隅角閉鎖型青光眼 33
5-2結果分析 34
5-2-1流體分析結果 34
5-2-2結構體分析結果 37
5-3結果驗證 39
5-4結果討論 44
5-4-1不同的眼壓與相同材料參數做比較討論 44
5-4-2相同的眼壓與不同的材料參數做比較討論 50
第六章結論與未來展望 59
6-1結論 59
6-2未來展望 61
參考文獻 62

圖目錄

圖1-1青光眼視野缺損的演進[5] 3
圖1-2房水流動示意圖[9] 5
圖2-1研究過程與流程圖 15
圖4-1FLUID 142元素圖[31] 24
圖4-2SOLID 45元素圖[31] 25
圖4-3眼球2D草圖繪製 30
圖4-4眼球模型剖面圖 30
圖4-5房水流場設定圖 31
圖4-6邊界條件示意圖 32
圖5-1隅角閉鎖型青光眼房水流動示意圖[41] 34
圖5-2隅角閉鎖型青光眼前後房壓力分布圖 35
圖5-3隅角閉鎖型青光眼前後房流場圖 36
圖5-4隅角閉鎖型青光眼前後房流線圖 36
圖5-5隅角閉鎖型青光眼之應力分布圖 38
圖5-6隅角閉鎖型青光眼應變分布圖 38
圖5-7隅角閉鎖型青光眼位移圖 39
圖5-8隅角閉鎖型青光眼與文獻[19]比較之應力分布圖 42
圖5-9隅角閉鎖型青光眼與文獻[24]比較之應力分布圖 43
圖5-10隅角閉鎖型青光眼與文獻[24]比較之應變分布圖 43
圖5-11不同眼壓與相同楊氏係數之應力分布比較圖 47
圖5-12不同眼壓與相同楊氏係數之應變分布比較圖 48
圖5-13不同眼壓與相同楊氏係數之位移比較圖 49
圖5-14相同眼壓(20mmHg)與不同楊氏係數之應力分布圖 52
圖5-15相同眼壓(20mmHg)與不同楊氏係數之應變分布圖 53
圖5-16相同眼壓(20mmHg)與不同楊氏係數之位移圖 54
圖5-17相同眼壓(40mmHg)與不同楊氏係數之應力分布圖 56
圖5-18相同眼壓(40mmHg)與不同楊氏係數之應變分布圖 57
圖5-19相同眼壓(40mmHg)與不同楊氏係數之位移圖 58

表目錄

表4-1房水材料參數表 26
表4-2模擬結構體眼球組織之材料參數表 28
表5-1隅角閉鎖型青光眼與文獻[19]之尺寸對照表 41
表5-2隅角閉鎖型青光眼與文獻[19]之楊氏係數對照表 41
表5-3隅角閉鎖型青光眼與文獻[19]之結果倍數比較表 41
表5-4隅角閉鎖型青光眼與文獻[24]之尺寸對照表 42
表5-5隅角閉鎖型青光眼與文獻[24]之楊氏係數對照表 43
表5-6不同眼壓與相同楊氏係數數據表 46
表5-7相同的眼壓與不同的楊氏係數數據表 51

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