淡江大學覺生紀念圖書館 (TKU Library)
進階搜尋


下載電子全文限經由淡江IP使用) 
系統識別號 U0002-2706201102471200
中文論文名稱 正常眼壓型青光眼之角膜厚度與眼球壓力分析
英文論文名稱 Corneal Thickness and Pressure Distribution Analysis of the Eyes of Normal-Tension Glaucoma
校院名稱 淡江大學
系所名稱(中) 機械與機電工程學系碩士班
系所名稱(英) Department of Mechanical and Electro-Mechanical Engineering
學年度 99
學期 2
出版年 100
研究生中文姓名 戴吉謙
研究生英文姓名 Ji-Chien Dai
學號 698370714
學位類別 碩士
語文別 中文
口試日期 2011-06-24
論文頁數 48頁
口試委員 指導教授-李宗翰
共同指導教授-黃曼菁
委員-牛仰堯
委員-洪祖昌
中文關鍵字 正常眼壓型青光眼  角膜  眼壓  房水 
英文關鍵字 Normal-tension glaucoma  cornea  intraocular pressure  aqueous humor 
學科別分類 學科別應用科學機械工程
中文摘要 正常眼壓型青光眼為青光眼病症的主要類型之一,多數的青光眼類型皆可以量測眼壓是否過高而察覺異狀,但正常眼壓型青光眼早期多無明顯症狀,且患者眼壓量測值皆位於正常範圍內,相較於一般青光眼病患較不易直接從眼壓上判斷病症。
青光眼是由於眼壓上升超出視神經所能負荷的範圍,使得視神經受損的一種視神經疾病,當眼壓高於視神經所能承受之限度時,便會使得視神經受損產生視野缺損,最後導致失明。目前量測的眼球內部壓力和真實眼壓仍存有誤差,中央角膜厚度即為主要的誤差因素,角膜較厚的患者眼壓容易被高估,反之低估了角膜較薄患者的眼壓,降低了青光眼判定的準確性。
本研究即為運用數值模擬分析的方式,對於正常眼壓型青光眼與角膜厚度的關係進行探討,並模擬患者眼球結構的壓力分佈及眼睛內部房水流動之情形,藉以了解角膜厚度對眼壓量測所造成的影響。
英文摘要 Normal-tension Glaucoma is one of the main types of glaucoma. Most types of glaucoma can be judged by their higher intraocular pressure. But, normal-tension glaucoma (NTG) shows no obvious symptoms, and the intraocular pressure is normal in its early stage. It is hard to tell if one having NTG by simply checking intraocular pressure value.
Glaucoma is a disease of optic nerve caused by increased intraocular pressure. An elevated intraocular pressure may irreversibly damage optic nerve which resulting in a progressive, permanent loss of vision when the pressure exceeds the load of optic nerve. In NTG, the measured value of internal pressure is not the real internal pressure. The major factor to cause this discrepancy is the thickness of central corneal. The thicker is the cornea, the overestimated is the intraocular pressure. The accuracy of the glaucoma diagnosis is then mis-conducted.
This study used numerical simulation to exam the relationship of normal-tension glaucoma and corneal thickness. The pressure distribution and the flow of aqueous humor in ocular structure are found and shown to know more of the impact of the corneal thickness and the value of intraocular pressure measured.
論文目次 目錄
中文摘要 I
英文摘要 III
目錄 V
圖目錄 VII
表目錄 VIII
第一章 緒論 1
1-1 研究背景與研究動機 2
1-2 文獻回顧 5
第二章 研究方法 7
2-1 有限元素法概述 7
2-2 應用軟體 8
第三章 分析理論 13
3-1 結構分析理論 13
3-2 流場分析理論 17
3-3 收斂檢測 19
第四章 角膜與眼壓量測 20
4-1 角膜 20
4-2 眼壓量測 21
第五章 分析元素、材料參數與邊界條件設定 24
5-1 模型分析元素 24
5-2 模擬材料參數 26
5-3 建立分析模型 28
5-4 初始條件 30
5-5 負載條件 33
第六章 正常眼壓型青光眼之模擬分析 35
6-1 正常眼壓型青光眼 35
6-2 正常眼壓型青光眼之模擬結果 36
第七章 結論與未來展望 41
7-1 結論 41
7-2 未來展望 42
參考文獻 43
專有名詞中英文對照表 48

圖目錄
圖1-1 眼球結構示意圖 2
圖1-2 房水流動示意圖 3
圖2-1 ANSYS分析處理作業流程圖 10
圖2-2 研究過程流程圖 12
圖4-1(A) Imbert-Fick定律示意圖 22
圖4-1(B) Imbert-Fick定律修正示意圖 22
圖5-1 SOLID45元素圖 24
圖5-2 FLUID142元素圖 25
圖5-3 眼球模型尺寸圖 29
圖5-4 眼球模型網格圖 29
圖5-5(A) 房水流場設定圖 31
圖5-5(B) 房水流場設定圖 32
圖5-6 模擬負載條件示意圖 33
圖6-1 前後房壓力分佈圖 37
圖6-2 房水流速分佈圖 37
圖6-3 房水流線分佈圖 38
圖6-4 角膜、水晶體和玻璃體壓力分佈圖 38
圖6-5 不同厚度的角膜壓力比較圖 40

表目錄
表5-1 房水材料參數表 26
表5-2 角膜與水晶體材料參數表 27
表5-3 玻璃體材料參數表 27

參考文獻 1.Canning, C. R. and Greaney, M. J., “Fluid flow in the anterior chamber of a human eye”, Southampton Eye Unit, 2002.
2.Doughty, M. J., Zaman, M. L., “Human corneal thickness and its impact on intraocular pressure measures: A review and meta-analysis approach”, Suvy Ophthalmol, Vol. 44, pp.367-408, 2000.
3.Doyle, A., Bensaid, A. and Lachkar, Y., “Central corneal thickness and vascular risk factors in normal tension glaucoma”, Journal of Acta Ophthalmologica Scandinavica, Vol. 83, Issue 2, pp.191-195, 2005.
4.Erik, D., Joel, D., Robert, L., Ian, P. and Stefan, M., “A Nonlinear Finite Element Model of the Human Eye for Large Deformation Loading”, Proceedings of 25th Annual Meeting of Biomechanics, pp. 44-45, 2001.
5.Ethier, C. R., Johnson M., and Ruberti, J., “OCULAR BIOMECHANICS and BIOTRANSPORT”, Annual Review of Biomedical Engineering, Vol.6, pp. 249–273, 2004.
6.Fick, A., “Ueber Messung des Druckes im Auge”, Ariv Fur Die Gesammte Physiologie Des Menschen & Der Thiere, Vol. 42, pp.86-90, 1888.
7.Glouster, J., Perkins, E. S., The validity of the Imbert-Fick law as applied to applanation tonometry. Exp Eye Res, Vol. 2, No. 3, pp.274-283, 1963.
8.Goldmann, H., Schmidt, T., Uber applanationstonometrie. Ophthalmologica, Vol. 134, No.4, pp.221-242, 1957.
9.Heys, J.J., Barocas, V. H. and Taravella, M.J., “Modeling Passive Mechanical Interaction Between Aqueous Humor and Iris”, Journal of Biomechanical, Vol.123, No.6, pp.540-547, 2001.
10.Imbert, A. “Theorie des ophtalmotonometres”, Arch Ophthalmol, Vol.5, pp.358-363, 1885.
11.Jeffrey, J., Victor, H., “A Boussinesq Model of Natural Convection in the Human Eye and the Formation of Krukenberg’s Spindle”, Annals of Biomedical Engineering, Vol. 30, pp. 392-401, 2002.
12.Johnson, M. and Erickson, K., “Mechanisms and routes of aqueous humor drainage”, Principles and Practice of Ophthalmology, Vol.4, pp.2577-2595, 2000.
13.Johnson, M., “What controls aqueous huour outflow resistance”, Experimental Eye Research, Vol. 82, No.4, pp. 545-557 , 2006.
14.Konareva-Kostianeva, M. I., Atanassov, M. A., “Central Corneal Thickness in Patients with Normal-tension Glaucoma”, Journal of Folia Medica, XLIX, 3&4, pp.36-41, 2007.
15.Kumar, S., “Numerical Solution of Ocular Fluid Dynamics”, Department of Mechanical Engineering, Louisiana State University, 2001.
16.Kumar, S., Achara, S., Beuerman, R. and Palkama, A., “Numerical Solution of Ocular Fluid Dynamics in a Rabbit Eye: Parametric Effects”, Annals of Biomedical Engineering, Vol. 34, pp. 530-544, 2006.
17.Levin, L.A., “Models of Neural Injury”, Journal of Glaucoma, Vol.10, pp. S19-S21, 2001.
18.Morad, Y., Sharon, E., Hefetz, L. and Nemet, P., “Corneal thickness and curvature in normal-tension glaucoma”, American Journal of Ophthalmology, Vol.125, No.2, pp.164-168, 1998.
19.Shields, M. B., Textbook of glaucoma, 4th ed. Baltimore; Williams & Wilkins, 1998.
20.Silver, D.M. and Quigley, H. A., “Aqueous Flow through the Iris–Lens Channel: Estimates of Differential Pressure between the Anterior and Posterior Chambers”, Journal of Glaucoma, Vol.13, pp.100-107, 2004.
21.Stitzel, J. D., Duma, S. M., Cormier J. M. and Herring, I. P., “A Nonlinear Finite Element Model of the Eye with Experimental Validation for the Prediction of Globe Rupture”, Journal of Stapp Car Crash, Vol. 46, pp.81-102, 2002.
22.Tripathi, R.C. and Tripathi, B.J. “Functional anatomy of the anterior chamber angle”, Biomedical Foundations of Ophthalmology Philadelphia, pp. 197, 1982.
23.Wang, T. H., “The Differential Diagnosis of Glaucomatous Optic Neuropathy”, ACTA Societatis Ophthalmologicae Sinicae, Vol. 48, No.4, pp.506-508, 2009.
24.Wasilewicz, R., Pecold-Stepniewska, H. and Pecold, K., “Central corneal thickness measurement in normal tension glaucoma”, Journal of Klin Oczna, Vol. 106, pp.236-237, 2004.
25.Whitacre, M. M., Stein R. “Sources of error with use of Goldmann-type tonometers” Surv Ophthalmol, Vol. 38, pp. 1-30, 1993.
26.Wu, L. L., Suzuki, Y., Ideta, R. and Araie, M. “Central Corneal Thickness of Normal Tension Glaucoma Patients in Japan”, Japanese journal of ophthalmology, Vol.44, pp.463-467, 2000.
27.Zhang, W. X., Li, C. L. and Wang, F., “Cinical application and biocompatibility of ophthalmic implants”, Journal of Clinical Rehabilitative Tissue Engineering Research, Vol. 13, No.42, 2009.
28.邱湘傑,「運用ANSYS FLOTRAN CFD於隅角閉鎖型青光眼在玻璃體外部所造成之壓力分析」,淡江大學 機械與機電工程研究所,2009。
29.黃士豪,「眼球前後房房水壓力數值模擬分析研究」,淡江大學 機械與機電工程研究所,2008。
30.趙蘭英, 「生醫材料的研究與發展」,工業技術研究院經資中心生醫組,2002。
31.蕭天偉,「超音波晶體乳化手術併人工水晶體植入於隅角閉鎖型青光眼治療之研究」,淡江大學 機械與機電工程研究所,2010。
32.ANSYS Release 12.0 Documentation
論文使用權限
  • 同意紙本無償授權給館內讀者為學術之目的重製使用,於2016-07-20公開。
  • 同意授權瀏覽/列印電子全文服務,於2016-07-20起公開。


  • 若您有任何疑問,請與我們聯絡!
    圖書館: 請來電 (02)2621-5656 轉 2281 或 來信