隅角開放型青光眼是青光眼中最常見的三大類型的其中一種，且經常伴隨著家族遺傳。其發生的原因是由於前房小樑網組織發生了問題，使得眼球前房引流系統異常，導致房水排出時受到阻礙而迫使眼壓升高，壓迫視神經，造成視神經盤凹陷與視野產生缺陷。    

   本研究以建立之數值模型擬對隅角開放型青光眼的生成與觸發機制進行模擬與分析，從後房房水生成到前房引流系統受阻，以致於眼壓升高對水晶體、玻璃體產生壓迫的狀況，並探討其對於視神經產生的影響。
   
   本研究結果顯示，隅角開放型青光眼在眼內產生的壓力確實存在傳遞的情形並實際影響眼球後方的視神經，導致視神經受到壓迫終究產生視野缺陷。

Primary Open Angle Glaucoma (POAG) is one of the three most common types of glaucoma, and is often associated with family disease history. The major cause for POAG is the adhesion at anterior trabecular meshwork tissue. This makes drainage system fails to function normally in anterior chamber, causes aqueous from anterior chamber hampered, and increased intraocular pressure. Then, Optic nerve is suppressed, optic disc is damaged, and visual field eventually is reduced. 

    The numerical model constructed in this study is to simulate the mechanism in forming POAG. Aqueous is generated from posterior chamber and flows into anterior chamber. As drainage system hampered, intraocular pressure increases and acts on the lens which creates oppression on vitreous and passes on the impact to optic nerve. 

    The results show that the pressure in the eyes of primary open angle glaucoma does transmit from lens to vitreous and actually affect the optic nerve on the back of an eye. This leads to optic nerve compression and vision defects.

目錄
摘要I
AbstractII
目錄IV
圖目錄VI
表目錄VIII
第一章 緒論1
1-1 前言1
1-2 研究動機與背景2
1-3 文獻回顧5
第二章 眼球構造、房水與眼壓7
2-1 眼球構造7
2-2 房水10
2-3 眼壓13
第三章 研究方法15
3-1 有限元素法理論15
3-2 數值分析理論16
3-3 收斂檢測21
3-4 應用軟體22
第四章 分析元素、材料參數與邊界條件設定27
4-1 定義分析元素27
4-2 設定材料參數29
4-3 建立實體模型31
4-4 初始條件34
4-5 負載條件36
第五章 結果與討論37
5-1 隅角開放型青光眼37
5-2 前後房房水壓力模擬39
第六章 結論與未來展望46
6-1 結論46
6-2 未來展望48
參考文獻49
專有名詞中英文對照表55

圖目錄
圖1-1青光眼後期視野圖4
圖2-1眼球內部構造示意圖9
圖2-2房水流動示意圖11
圖3-1ANSYS作業流程圖24
圖3-2研究過程流程圖26
圖4-1FLUID142元素圖27
圖4-2 SOLID45元素圖28
圖4-3眼球前後房模型圖32
圖4-4眼球水晶體與玻璃體模型圖32
圖4-5眼球前後房模型網格圖33
圖4-6眼球水晶體與玻璃體模型網格圖33
圖4-7(a)房水流場設定圖34
圖4-7(b)房水流場設定圖35
圖4-8模擬負載條件示意圖36
圖5-1隅角開放型青光眼示意圖38
圖5-2隅角開放型青光眼前後房之壓力分佈圖39
圖5-3隅角開放型青光眼前後房之流速分佈圖40
圖5-4隅角開放型青光眼前後房之流場流線分佈圖40
圖5-5隅角開放型青光眼與正常人眼球之壓力比較圖42
圖5-6隅角開放型青光眼與正常人眼球之流速比較圖42
圖5-7隅角開放型青光眼與正常人眼球之流場流線比較圖43
圖5-8隅角開放型青光眼水晶體與玻璃體之壓力分佈圖44
圖5-9正常人眼球水晶體與玻璃體之壓力分佈圖44
圖5-10隅角開放型青光眼眼壓壓力分佈圖45

表目錄
表4-1房水材料參數表29
表4-2水晶體材料參數表30
表4-3玻璃體材料參數表30

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