心臟病的末期病患，在藥物控制與傳統手術均無法治療的情況下只有換心一途，但心臟捐贈者遠不及需要換心的病患，遂而發展出替代的心室輔助器。本文以純流體動力軸承軸流式心室輔助器為設計，並以計算流體力學進行初步模擬，目標為流量Q=5 L/min及100 mm Hg的壓差。而介於定子與轉子間的潤滑薄層為50μm，且能產生潤滑及軸頸軸承的作用。以蒸餾水溶液測試在轉速11,000 rpm時流量可達5 L/min，最大壓差為50 mm Hg，而利用體積比36%甘油與64%蒸餾水混合成血液模擬溶液進行實驗量測，在轉速9,000 rpm時流量可達5 L/min，最大壓差為25 mm Hg，雖不達設計目標，但從幫浦性能曲線圖之趨勢來看，轉速增加時，流量與壓力均會提升。

Cardiovascular disease is the major leading cause of death world wide. The success rate for heart replacement surgery exceeds 90 %, but the demand exceeds the supply. While waiting for a replacement, the patients must rely temporarily on artificial hearts or ventricular assist devices (VAD). The purpose of this study is to design an axial blood pump by using the hydrodynamic bearing theory, and simulate the initial design by the Computational Fluid Dynamics (CFD) method, which exceed the 5 L/min flow rate and 100 mm Hg pressure head. The fluid-film size between the rotor and stator is 50μm, which can account for lubrication and journal bearing. This pump was tested in distilled water which can produce a flow rate of 5 L/min with 50 mm Hg pressure head increase at 11,000 rpm. And it was tested in blood fluid analog which was 36% aqueous glycerin and 64% distilled water by volume. The result indicated that it can produce a flow rate of 5 L/min with 25 mm Hg pressure head increase at 9,000 rpm. Although the result does not reach the design object, but from the trend of pump performance curve, the flow rate and the pressure head all arise when the revolutions per minute increased.

目錄
中文摘要.................................................................................................... I
Abstract....................................................................................................II
謝誌.........................................................................................................III
目錄..........................................................................................................IV
圖目錄......................................................................................................VI 
表目錄......................................................................................................IX 
第一章	緒論..............................................................................................1
1.1	前言..............................................................................................1
1.2	研究目的與背景..........................................................................2
1.3	研究過程......................................................................................4
第二章	文獻回顧......................................................................................6
2.1	全人工心臟與心室輔助器的發展..............................................6
2.2	歷代心室輔助器之比較..............................................................9
2.2.1	 第一代心室輔助器................................................................9
2.2.2	 第二代心室輔助器..............................................................10
2.2.3	 第三代心室輔助器..............................................................12
2.3	本研究與其他設計者的比較....................................................14
第三章	設計與實驗................................................................................15 
3.1	設計原理─Hydrodynamic Bearing...........................................15 
3.2	心室輔助器設計概要................................................................20 
3.3	模型設計....................................................................................21 
3.4	計算流體力學模擬....................................................................27 
3.5	實驗量測及結果........................................................................31 
3.5.1	 實驗設備..............................................................................31 
3.5.2	 實驗方法..............................................................................35 
3.5.3	 實驗結果..............................................................................37 
第四章	結果與討論................................................................................39 
4.1	實驗結果與討論........................................................................39 
4.2	設計上的缺失............................................................................46 
4.3	建議與改進................................................................................51 
4.3.1	 設計與加工..........................................................................51 
4.3.2	 模型製造改進......................................................................52 
4.3.3	 CFD模擬的困難.................................................................55 
第五章	結論............................................................................................56 
參考文獻..................................................................................................57 



圖目錄
圖1-1 研究流程示意圖............................................................................5
圖2-1 Abiomed BVS 5000.........................................................................7
圖2-2 HeartMate IP LVAS........................................................................7
圖2-3 Novacor LVAD...............................................................................7
圖2-4 Thoratec Pneumatic VAD System...................................................7
圖2-5 Micromed DeBakey VAD.............................................................11
圖2-6 HeartMate II LVAS.......................................................................11
圖2-7 First in vivo trial of  25 valvo-pump in an 80kg pig
 ....................................................................................................13
圖3-1 Hydeodynamic pressures generated by journal rotation in a 
cylindrical bearing........................................................................16  
圖3-2 Low Reynolds number Couette flow in a varying gap..................17
圖3-3 shaft and pad side view..................................................................18
圖3-4 轉子剖面設計圖..........................................................................21
圖3-5 轉子模型......................................................................................21
圖3-6 定子剖面設計圖..........................................................................22
圖3-7 壓力出口示意圖..........................................................................22
圖3-8 定子模型......................................................................................23
圖3-9 磁鐵之(a) side view (b) top view.................................................23
圖3-9 磁鐵之(c)埋設位置 (d)定子剖面圖...........................................24
圖3-10瓦型永久磁鐵..............................................................................24
圖3-11 葉片設計圖(a) side view、(b) front view ..................................25
圖3-12 葉片模型....................................................................................25
圖3-13 (a) 轉子與葉片、(b) 機械軸承軸流氏心室輔助器葉片..........26
圖3-14 gap位置圖...................................................................................26
圖3-15 葉片轉動後之速度流場............................................................28
圖3-16 葉片出流端之速度流場............................................................28
圖3-17 葉片出流端速度流場分布放大圖............................................29
圖3-18 XY斷面之速度流場..................................................................29
圖3-19 壓力分布圖................................................................................30
圖3-20 超生波流量計............................................................................31
圖3-21 示波器........................................................................................31
圖3-22 (a) 壓力放大器、(b) 壓力轉換器..............................................32
圖3-23 電源供應器................................................................................32
圖3-24 電流探棒....................................................................................33
圖3-25 (a) 無刷直流馬達、(b) 馬達控制器........................................34
圖3-26 實驗平台示意圖........................................................................36
圖3-27 實驗平台....................................................................................36
圖3-28 H-Q characteristic curve of the axial blood pump
       (蒸餾水).................................................................................... 37
圖3-29 H-Q characteristic curve of the axial blood pump 
(甘油加水).................................................................................38
圖4-1 Pressure coefficient versus flow coefficient (蒸餾水)..................42
圖4-2 Pressure coefficient versus flow coefficient (甘油加水)..............42
圖4-3 Power coefficient versus flow coefficient (蒸餾水)......................43
圖4-4 Power coefficient versus flow coefficient (甘油加水)..................43
圖4-5 Specific speed versus specific coefficient (蒸餾水)......................44
圖4-6 Specific speed versus specific coefficient (甘油加水)..................44
圖4-7 Cordier diagram showing empirical relationship between 
specific speed   and specific diameter   for pump       
and fans.......................................................................................45 
圖4-8 wall shear stress (1).......................................................................48
圖4-9 wall shear stress (2).......................................................................48
圖4-10 轉子1/4剖面圖..........................................................................53
圖4-11 葉片設置位置圖........................................................................54


表目錄
表3-1 無刷直流馬達尺寸規格表..........................................................33
表4-1 無因次化參數之單位與對應常數表..........................................40

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