系統識別號 | U0002-1907201815470900 |
---|---|
DOI | 10.6846/TKU.2018.00572 |
論文名稱(中文) | 柯斯迴歸之現狀數據的樣本數計算 |
論文名稱(英文) | Sample Size Calculations for the Cox Regression with Current Status Data |
第三語言論文名稱 | |
校院名稱 | 淡江大學 |
系所名稱(中文) | 數學學系數學與數據科學碩士班 |
系所名稱(英文) | Master's Program, Department of Mathematics |
外國學位學校名稱 | |
外國學位學院名稱 | |
外國學位研究所名稱 | |
學年度 | 106 |
學期 | 2 |
出版年 | 107 |
研究生(中文) | 張妤涵 |
研究生(英文) | Yu-Han Chang |
學號 | 605190163 |
學位類別 | 碩士 |
語言別 | 繁體中文 |
第二語言別 | |
口試日期 | 2018-06-26 |
論文頁數 | 34頁 |
口試委員 |
指導教授
-
温啓仲(ccwen@mail.tku.edu.tw)
委員 - 黃逸輝(yhhuang@mail.tku.edu.tw) 委員 - 吳裕振(yuhjenn@cycu.edu.tw) |
關鍵字(中) |
存活分析 比例風險模型 積分樣條函數 檢定力 |
關鍵字(英) |
Survival analysis Power Proportional hazards model Integrated Splines |
第三語言關鍵字 | |
學科別分類 | |
中文摘要 |
現狀數據常見於社會學、流行病學及醫學研究中。此數據皆無法直接觀測研究事件的真實發生時間,僅能在檢查或調查時間當下得知事件是否已發生。Williamson, Lin and Kim (2009) 對於以 Weibull 為基線分佈的柯斯迴歸提出一個現狀數據的樣本數計算。然而,在過去的研究中,說明柯斯迴歸模型在不同母數的基線模型下,所需的樣本數可能有極大的差異。因此本論文對於以積分樣條模型 (I-splines) 模式未特定基線分佈的半母數柯斯迴歸,提供一個現狀數據樣本數的計算公式。透過模擬驗證公式的正確性,並以兩個實例作為公式的例證。 |
英文摘要 |
Current status data are commonly arisen in sociology, epidemiology and medical studies, where we cannot directly observe the actual occurrence time of the research event. The only be observation consists of the time of inspection and a status indicator of the event has occurred by the time of inspection. Williamson, Lin and Kim (2009) proposed a sample size calculation for current status data under the Cox model with Weibull baseline. However, in previous studies, it was shown that samples sizes required for the Cox regression with different baseline models may vary greatly. In this thesis, we provide a sample size formula for semiparametric Cox regression analysis of current status data under unspecified baseline distribution. The baseline distribution is modelled by I-splines (Ramsay 1988). The proposed formula is verified by simulation studies and illustrated by two real examples. |
第三語言摘要 | |
論文目次 |
目錄 第一節 前言 1 第二節 方法 4 第三節 模擬試驗 12 第四節 實例分析 19 RFM老鼠肺腫瘤數據分析 19 白內障數據分析 24 第五節 結論與討論 29 參考文獻 31 附錄 34 表目錄 表 3-1(a) 15 表 3-1(b) 16 表 3-1(c) 17 表 3-1(d) 18 表 4-1(a) 22 表 4-1(b) 23 表 4-2 27 圖目錄 圖 2-1 7 圖 4-1 21 圖 4-2 25 圖 4-3 26 |
參考文獻 |
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