許多的統計資料指出，心血管疾病是現代人死亡原因的前幾名，而心臟瓣膜的疾病就是其中的一種，然而目前之人工機械心瓣仍存在有溶血與血栓的問題，而溶血是紅血球遭受機械外力破壞、血栓則是血小板受到機械力破壞。本研究利用毛細管流流場，裝設兩種不同的毛細管流場量測血球受層流剪應力破壞的溶血閥值。而過去學者多用coutte flow等裝置設置流場，故可以做比較。另一方面，也同時對不同的暴露時間於毛細管流中的溶血現象做討論。

A lot of statistical data indicate that cardiovascular disease is the first several cause of death of modern people, and heart valve disease is one of them. However, an artificial mechanical heart valve at present still has problems with hemolysis and thrombosis, and red blood cell hemolysis is the subject mechanical external damage, thrombosis is platelet destruction by mechanical force. In this study, by utilizing capillary flow field, installing two different capillary flow fields to measure the hemolytic valve value of blood cells damaged by laminar shear stress. In the past, scholars used other devices with coutte flow to set up flow field. The flow field in this experiment.So this study can be compared with previous studies. On the other hand, the different exposure time in the capillary flow of hemolysis is also discussed in this thesis.

目錄
目錄	I
圖目錄	III
表目錄	VI
第一章 緒論	1
    1-1 前言	1
    1-2 研究動機和目的	2
    1-3 研究過程	3
第二章 文獻回顧	4
    2-1 血球破壞閥值	4
第三章 實驗設置與方法	9
    3-1 血球破壞閥值	9
        3-1-1 管流	9
        3-1-2 流場設置	11
        3-1-3 儲血注射器	22
    3-2 實驗周邊設置	23
    3-3 血液相關與藥品製備	26
        3-3-1 溶血現象	26
        3-3-2 藥品製備	26
        3-3-3 採血器具之準備	27
        3-3-4 血液的採集	29
    3-4 溶血實驗	30
        3-4-1毛細管層流流場實驗	30
        3-4-2樣本分析	34
第四章 結果與討論	36
    4-1血液分析結果	36
    4-2溶血模式比較	51
第五章 結論與建議	59
參考文獻	61
     
圖目錄
圖3-1. 圓管流入口長度示意圖	11
圖3-2. 實驗設置組體圖	12
圖3-3. 實驗設置主體照	13
圖3-4. 總長度Lt=15cm之毛細管	16
圖3-5. 總長度Lt=10cm之毛細管	16
圖3-6. 剪應力與暴露時間關係(5、10cm)	18
圖3-7. 毛細管連接示意圖	20
圖3-8. 儲血注射器(reservoir region)	23
圖3-9. 數值型黏度計	24
圖3-10. 注射器馬達正面圖	25
圖3-11. 注射器馬達上視圖	25
圖3-12. 黏度計裝設圖	30
圖3-13. 黏度計裝設圖	31
圖3-14. 黏度計裝設圖	31
圖3-15. 裝設實驗圖	32
圖3-16. 裝設實驗上視圖	32
圖3-17. 裝設實驗側面圖	32
圖3-18. 接收樣本至試管	33
圖3-19. 接收樣本至試管	33
圖4-1.  Lt=5cm  A瓶血溶血指數IH(%)	38
圖4-2.  Lt=5cm  B瓶血溶血指數IH(%)	38
圖4-3.  A瓶血溶血指數IH(%)趨勢圖，Lt=5cm	39
圖4-4.  B瓶血溶血指數IH(%)趨勢圖，Lt=5cm	40
圖4-5.  綜合A、B資料溶血指數IH(%)趨勢圖，Lt=5cm	41
圖4-6.  Lt=10cm  C瓶血溶血指數IH(%)	45
圖4-7.  Lt=10cm  D瓶血溶血指數IH(%)	45
圖4-8.  C瓶血溶血指數IH(%)趨勢圖，Lt=10cm	46
圖4-9.  D瓶血溶血指數IH(%)趨勢圖，Lt=10cm	47
圖4-10.  C、D瓶血差異性比較，Lt=10cm	48
圖4-11.  綜合C、D資料溶血指數IH(%)趨勢圖，Lt=10cm	49
圖4-12.  溶血指數IH(%)趨勢圖比較，Lt=10cm與Lt=5cm	50
圖4-13.  Presentation of the experimentally obtained	54
圖4-14.  Illustrated is the flow induced blood damage by shear stresses of up to 450 Pa and exposure times up to 1,238ms.	55
圖4-15.　Coutte flow層流實驗結果(Lu et al. 2010)	56

表目錄
表2-1.  溶血研究學者列表	8
表3-1.  暴露時間對應剪應力表	17
表3-2.  Ltotal=5 cm之各項參數關係表	21
表3-3.  Ltotal=10 cm之各項參數關係表	22
表4-1.  Lt=5cm 豬隻B各應力下O.D.值與IH值	36
表4.2  Lt=5cm 豬隻B各應力下O.D.值與IH值	37
表4-3.  Lt=10 豬隻C應力下O.D.值與IH值	43
表4-4.  Lt=10 豬隻D力下O.D.值與IH值	44
表4-5.  實驗結果與各學者比較	52
表4-6. 溶血閥值及暴露時間比較	58

參考文獻
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