傳統用來溶解疏水性高分子進行靜電紡絲製程的溶劑，如二氯甲烷、氯仿、二甲基甲醯胺、甲苯等，對環境及健康的危害性高，多數受行政院環境保護署公告列管，尋求較無害及環保的溶劑為重要課題。
    本研究以環保溶劑溶解聚甲基丙烯酸乙酯(poly(ethylmethacrylate), PEMA)，以靜電紡絲製備疏水性高分子次微米纖維。研究中分為以異丙醇/水共溶劑、1-甲氧基-2-丙醇溶劑溶解PEMA進行電紡實驗。異丙醇和水不能單獨溶解疏水性的高分子，研究中使用不同異丙醇/水比例的共溶劑溶解PEMA溶液，期望本研究之系統及製程能達到永續環保的特點。
    配置的溶液加熱攪拌溶解並冷卻至室溫持續攪拌，選擇在連續攪拌第三天黏度穩定時作為實驗的製程，先利用ne值對濃度作圖與比黏度對濃度之對數作圖預測電紡情況，再於室溫下進行靜電紡絲實驗。研究中改變靜電紡絲製程條件，瞭解不同變因（濃度、溶劑比例、電壓、工作距離、流速等）對紡出纖維型態的影響。在適當的條件下可得完全纖維型態，纖維以掃描式電子顯微鏡觀察後計算得直徑約為0.9 μm~ 4.5 μm，對水的接觸角可大於130°，具疏水性。紡絲成品使用FTIR-ATR、TGA、DSC進行結構及熱性質分析。

Solvents commonly used to dissolve hydrophobic polymers for electrospinning processes are dichloromethane, chloroform, dimethylformamide, toluene, etc. They are harmful to the environment and health, thus most of them are under monitoring and inspection by Environmental Protection Administration of Taiwan. It is an important issue to search for harmless and environmentally friendly solvents.
    In this study, poly(ethylmethacrylate), (PEMA) was dissolved in environmentally friendly solvent or cosolvent, such as 2-propanol/water, 1-methoxy-2-propanol to prepare submicron fibers by electrospinning. 2-Propanol and water cannot dissolve hydrophobic polymers, thus cosolvents with different ratios were used to prepare PEMA solutions.  It is expected that the system and process of this study can achieve sustainable environmental protection.
    The polymer solutions were heated and stirred for 6 hours, and stirred continuously at room temperature for 3 days. Then, the solutions were electrospun at room temperature. Two methods, the graph of ne value versus the concentration and the specific viscosity versus the logarithm of the concentration were employed to predict the electrospinning situation. The electrospinning process conditions (concentration, solvent ratio, voltage, working distance, flow rate, etc.) were changed to understand the influence of different variables on fiber types and diameters. Under appropriate conditions, defect-free fibers can be obtained. Fibers diameter are calculated to be about 0.9 μm~ 4.5 μm after observation through a scanning electron microscope. Electrospun fiber membranes  were superb hydrophobicly with contact angles more than 130°. The structural and thermal properties were analyzed by FTIR (ATR), TGA, and DSC.

目錄
致謝	I
目錄	V
圖目錄	VII
表目錄	IX
第一章 前言	1
第二章 文獻回顧	4
2.1靜電紡絲技術	4
2.2靜電紡絲之參數	5
2.2.1溶液參數(solution parameters)	6
2.2.2操作參數(process parameters)	10
2.2.3環境參數(ambient parameters)	13
2.3靜電紡絲溶劑選擇	14
2.4研究目的	16
第三章 實驗	17
3.1實驗材料	17
3.2實驗方法及流程	19
3.3電紡設備及分析儀器	21
第四章 結果與討論	23
4.1 IPA/water共溶劑	23
4.1.1 PEMA溶液性質	23
4.1.2溶液濃度之影響	26
4.1.3共溶劑比例之影響	29
4.1.4靜電紡絲操作變因之影響	34
4.2 NPA/water共溶劑	40
4.2.1共溶劑之比較	40
4.2.2溶液濃度之影響	41
4.2.3靜電紡絲操作變因之影響	47
4.3 PM純溶劑	53
4.3.1溶劑之比較	53
4.3.2溶液濃度之影響	54
4.3.3靜電紡絲操作變因之影響	58
4.4 PEMA纖維性質分析	66
4.4.1物性分析	66
4.4.2 FTIR分析	68
4.4.3熱性質分析	71
第五章 結論	75
第六章 參考文獻	76
附錄A	79
附錄B	80
附錄C	81
附錄D	82
附錄E	83
 
圖目錄
圖1-1靜電紡絲示意圖	1
圖2-1不同分子量PLA溶於DMF/DCM共溶劑ne隨濃度變化圖	6
圖2-2固定25 wt%下不同重量分子量PVA纖維	7
圖2-3表面張力及黏度對PVP 4 wt%不同比例ethanol/DMF圖	9
圖2-4不同電壓下靜電紡絲的噴頭型態	11
圖2-5 PEO不同電壓-流速的操作點	12
圖2-6 PEMA膜與電紡纖維DSC圖	15
圖3-1 PEMA靜電紡絲實驗流程	20
圖4-1不同濃度PEMA溶於異丙醇/水= 8/2溶液之ne值	23
圖4-2異丙醇/水= 8/2不同濃度於室溫下攪拌第3天測得之黏度	24
圖4-3異丙醇/水= 8/2比黏度對濃度之對數作圖	25
圖4-4不同濃度PEMA溶液電紡的纖維型態	27
圖4-5電紡溶液之纖維平均直徑分布	28
圖4-6固定濃度為5.7 wt%不同溶劑比例黏度、表面張力圖	30
圖4-7電紡異丙醇/水= 7.5/2.5的5.7 wt%溶液之纖維型態	31
圖4-8電紡異丙醇/水= 7.8/2.2的5.7 wt%溶液之纖維型態	31
圖4-9電紡異丙醇/水= 8/2的5.7 wt%溶液之纖維型態	32
圖4-10電紡異丙醇/水= 8.5/1.5的5.7 wt%溶液之纖維型態	32
圖4-11電紡異丙醇/水= 9/1的5.7 wt%溶液之纖維型態	33
圖4-12電紡異丙醇/水= 9.5/0.5的5.7 wt%溶液之纖維型態	33
圖4-13電紡異丙醇/水= 8/2的5.7 wt%溶液電壓為10.5 kV之纖維型態	35
圖4-14電紡異丙醇/水= 8/2的5.7 wt%溶液電壓為13 kV之纖維型態	35
圖4-15固定濃度為5.7 wt%不同溶劑比例不同電壓之纖維直徑	36
圖4-16電紡異丙醇/水= 8/2的5.7 wt%工作距離12 cm之纖維型態	38
圖4-17電紡異丙醇/水= 8/2的5.7 wt%工作距離15 cm (13 kV)纖維型態	38
圖4-18電紡異丙醇/水= 8/2的5.7 wt%工作距離15 cm (16 kV)纖維型態	39
圖4-19電紡異丙醇/水= 8/2的5.7 wt%工作距離15 cm (19 kV)纖維型態	39
圖4-20不同濃度PEMA溶於正丙醇/水= 7.5/2.5溶液之ne值	41
圖4-21正丙醇/水= 7.5/2.5不同濃度於室溫下攪拌第3天測得之黏度	42
圖4-22電紡正丙醇/水= 7.5/2.5的5.7 wt%溶液之纖維型態	44
圖4-23電紡正丙醇/水= 7.5/2.5的6.5 wt%溶液之纖維型態	45
圖4-24電紡正丙醇/水= 7.5/2.5的7.4 wt%溶液之纖維型態	45
圖4-25電紡正丙醇/水= 7.5/2.5的9.1 wt%溶液之纖維型態	46
圖4-26電紡正丙醇/水= 7.5/2.5的10.7 wt%溶液之纖維型態	46
圖4-27電紡正丙醇/水= 8/2的6.5 wt%溶液之纖維型態	46
圖4-28電紡正丙醇/水= 7.5/2.5的6.5 wt%溶液電壓為13 kV之纖維型態	48
圖4-29電紡正丙醇/水= 7.5/2.5的6.5 wt%溶液電壓為16 kV之纖維型態	48
圖4-30電紡正丙醇/水= 7.5/2.5的6.5 wt%溶液電壓為19 kV之纖維型態	49
圖4-31電紡正丙醇/水= 7.5/2.5的6.5 wt%溶液電壓為22 kV之纖維型態	49
圖4-32正丙醇/水= 7.5/2.5不同濃度不同電壓之纖維直徑	50
圖4-33電紡正丙醇/水= 7.5/2.5的10.7 wt%工作距離為12 cm之纖維型態	52
圖4-34電紡正丙醇/水= 7.5/2.5的10.7 wt%工作距離為15 cm之纖維型態	52
圖4-35不同濃度PEMA溶於1-甲氧基-2-丙醇溶液之ne值	54
圖4-36電紡1-甲氧基-2-丙醇的10 wt%溶液之纖維型態	56
圖4-37電紡1-甲氧基-2-丙醇的12 wt%溶液之纖維型態	56
圖4-38電紡1-甲氧基-2-丙醇的13.5 wt%溶液之纖維型態	56
圖4-39電紡1-甲氧基-2-丙醇的15 wt%溶液之纖維型態	57
圖4-40電紡1-甲氧基-2-丙醇的15 wt%溶液電壓為13 kV之纖維型態	59
圖4-41電紡1-甲氧基-2-丙醇的15 wt%溶液電壓為16 kV之纖維型態	59
圖4-42電紡1-甲氧基-2-丙醇的15 wt%溶液電壓為19 kV之纖維型態	60
圖4-43電紡1-甲氧基-2-丙醇的15 wt%工作距離為18 cm之纖維型態	62
圖4-44電紡1-甲氧基-2-丙醇的15 wt%工作距離為20 cm之纖維型態	62
圖4-45電紡1-甲氧基-2-丙醇的15 wt%流速為0.1 ml/min 22 kV之纖維型態	64
圖4-46電紡1-甲氧基-2-丙醇的15 wt%流速為0.15 ml/min 22 kV之纖維型態	64
圖4-47電紡1-甲氧基-2-丙醇的15 wt%流速為0.15 ml/min 28 kV之纖維型態	65
圖4-48電紡1-甲氧基-2-丙醇的15 wt% 3分鐘之纖維型態	67
圖4-49電紡1-甲氧基-2-丙醇的15 wt% 20分鐘之纖維型態	67
圖4-50 PEMA粉粒與溶劑比例異丙醇/水= 8/2纖維之FTIR-ATR光譜圖	69
圖4-51 PEMA粉粒與不同溶劑紡絲纖維之FTIR-ATR光譜圖	70
圖4-52 PEMA粉粒與溶劑比例異丙醇/水= 8/2纖維DSC一次升溫分析圖	72
圖4-53 PEMA粉粒與溶劑比例異丙醇/水= 8/2纖維DSC二次升溫分析圖	72
圖4-54 PEMA粉粒與不同溶劑紡絲纖維DSC一次升溫分析圖	73
圖B-1異丙醇/水= 8/2不同濃度於室溫下攪拌5天測得之黏度	80
圖E-1 PEMA粉粒及紡絲纖維之熱重損失圖	83
圖E-2 PEMA粉粒及紡絲纖維之熱重損失微分圖	84
 
表目錄
表1-1靜電紡絲之應用	2
表1-2標準大氣壓下溶劑性質表	3
表2-1利用不同經驗法預測PEMA於有機溶劑的溶解度	14
表2-2高分子及不同溶劑之溶解度參數	16
表3-1標準大氣壓下溶劑物性表	18
表3-2正丙醇、異丙醇與水形成的二元共沸物	18
表4-1異丙醇/水= 8/2不同濃度之纖維直徑、接觸角	26
表4-2濃度5.7 wt%不同溶劑比例之溶液性質、纖維直徑、接觸角	30
表4-3異丙醇/水= 8/2的5.7 wt%不同電壓之纖維直徑、接觸角	34
表4-4異丙醇/水= 8/2的5.7 wt%不同工作距離之纖維直徑、接觸角	37
表4-5異丙醇/水和正丙醇/水5.7 wt%不同溶劑比例下第3天之黏度	40
表4-6正丙醇/水= 7.5/2.5不同濃度之纖維直徑、接觸角	44
表4-7正丙醇/水= 7.5/2.5的6.5 wt%不同電壓之纖維直徑、接觸角	47
表4-8正丙醇/水= 7.5/2.5的10.7 wt%不同工作距離之纖維直徑、接觸角	51
表4-9不同溶劑 10 wt%第3天之黏度、表面張力	53
表4-10 1-甲氧基-2-丙醇不同濃度之纖維直徑、接觸角	55
表4-11 1-甲氧基-2-丙醇的15 wt%不同電壓之纖維直徑、接觸角	58
表4-12 1-甲氧基-2-丙醇的15 wt%不同工作距離之纖維直徑、接觸角	61
表4-13 1-甲氧基-2-丙醇的15 wt%不同流速之纖維直徑、接觸角	63
表4-14 1-甲氧基-2-丙醇不同紡絲時間之纖維直徑、接觸角	66
表4-15 PEMA粉粒與溶劑比例異丙醇/水= 8/2纖維DSC數據分析	74
表4-16 PEMA粉粒與不同溶劑紡絲纖維DSC數據分析	74
表A-1靜電紡絲不銹鋼針規格	79
表E-1高分子原料及紡絲纖維之熱重損失數據	84

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