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系統識別號 U0002-0701201016175200
中文論文名稱 新型三葉人工心瓣關閉動力研究
英文論文名稱 The closing dynamics of a new trileaflet heart valve
校院名稱 淡江大學
系所名稱(中) 水資源及環境工程學系碩士班
系所名稱(英) Department of Water Resources and Environmental Engineering
學年度 98
學期 1
出版年 99
研究生中文姓名 陳孝杰
研究生英文姓名 Hsiao-Chien Chen
學號 696480093
學位類別 碩士
語文別 中文
口試日期 2009-12-31
論文頁數 85頁
口試委員 指導教授-盧博堅
委員-陳炤彰
委員-戴璽恆
中文關鍵字 機械心瓣  穴蝕現象  葉片關閉速度  壓力擾動之均方根值  左心室負載率 
英文關鍵字 mechanical heart valve  Cavitation  the valve closing velocity  root mean square of pressure fluctuation  the loading rate 
學科別分類 學科別應用科學環境工程
中文摘要 目前臨床使用的人工機械心瓣可能會導致穴蝕的發生,造成心瓣本身與血球的破壞,並可能導致溶血與血栓的生成。穴蝕現象主要在葉片關閉的瞬間產生,因此與心瓣的關閉機制有很大的關聯。由於目前仍未有完美的人工心瓣,因此新型人工心瓣的設計與開發仍在不斷進行中。本研究針對穴蝕現象的生成,利用本實驗室所研發的新型三葉片機械心瓣與臨床上使用廣泛之St. Jude Medical雙葉片機械心瓣及Medtronic-Hall Standard 單葉片心瓣在體外模擬測試台中進行測試。實驗結果指出在葉片關閉速度、最大負壓(NPP)、壓力擾動之均方根值(RMS)以及左心室負載率(dp/dt)這些與穴蝕現象生成有關的各參數中,三葉片機械心瓣的表現較其他兩個心瓣為佳;而利用高速攝影機拍攝心瓣關閉瞬間的穴蝕汽泡影像的結果發現三葉片機械心瓣未有明顯的穴蝕汽泡生成,因此本實驗室所設計之三葉片機械心瓣其關閉行為應較其他單雙葉片心瓣設計為佳。
英文摘要 Cavitation inception caused by clinical implanted mechanical heart valve (MHV) may destroy the constitution of MHV and blood cells, and it also may induce hemolysis and thrombosis. The closing mechanisms of MHV are more relevant to cavitation inception because the cavitation bubbles often be observed at the instant of MHV closure. To date, the new design of artificial heart valves are still developing because there are no perfect artificial valves yet. In this study, we used the new design Trileaflet MHV of our laboratory to study the inception of cavitation in in vitro physiological mock loop. We also used the St. Jude medical MHV (SJM) and Medtronic Hall standard MHV (MHS), which are implanted extensively in clinical, to compare the results of Trileaflet MHV.
Our results indicated that the valve closing velocity, the negative peak pressure (NPP), the root mean square of pressure fluctuation (RMS), and the loading rate (dp/dt), which are the important factors of cavitaion inception, were lower in Trileaflet MHV than SJM and MHS, and the cavitaion bubbles images captured from high speed CCD camera also displayed the unobvious cavitation bubbles in Trileaflet MHV than other two MHVs. This illustrate that the closing behavior of our new design trileaflet MHV is better than the monoleaflet and bileaflet MHVs.
論文目次 目錄
目錄 I
圖目錄 II
表目錄 IV
第一章 緒論 1
1-1 前言 1
1-2研究動機與目的 4
1-3研究程序 6
第二章 文獻回顧 8
2-1 人工機械心瓣 8
2-2 機械心瓣的問題 10
2-3 穴蝕成因 11
2-3.1 水錘效應(Water Hammer) 12
2-3.2 文氏效應(Venturi effect) 14
2-3.3 擠壓流(squeeze flow) 15
2-3.4 渦流現象(vortex effect) 16
2-4 三葉片的相關文獻 17
第三章 實驗方法與裝置 19
3-1體外脈動模擬裝置 19
3-2 壓力計 23
3-3 拍攝及量測儀器 25
3-4 實驗方法及流程 27
第四章 結果與討論 31
4-1 主動脈與左心室壓力波形 31
4-2 PCB壓力訊號及葉片的關閉速度 42
4-3 拍攝結果 49
4-4 資料分析 74
第五章 結論與建議 77
參考文獻 80
附表 83

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